,以及有機(jī)化學(xué)專業(yè)雜志JOC 2篇。研究方向1. 抗菌和抗腫瘤的微生物次級代謝產(chǎn)物的生物合成和組合生物合成 微生物次代謝物是由微生物產(chǎn)生的天然產(chǎn)物
。 2. 微生物來源的生理活性天然產(chǎn)物的篩選和鑒定 自20世紀(jì)20年代末青霉素的發(fā)現(xiàn)至今,微生物仍然是藥物和藥物先導(dǎo)化合物的重要來源
。 3. 酶作為生物催化劑在有機(jī)合成中的套用 酶作為重要的生物催化劑,具有優(yōu)異的化學(xué)選擇性
。發(fā)表論文主要代表性論文: 1. Lin SJ, Van Lanen SG and Shen B*, “A Free-Standing Condensation Enzyme Catalyzing Ester Bond Formation in C-1027 Biosynthesis”. Proc. Natl. Acad. Sci. U.S.A. 2009,106, 4183-4188. 2. Lin SJ, Van Lanen SG and Shen B*, “Characterization of the Two-Component, FAD-Dependent Monooxygenase SgcC that Requires Carrier Protein-Tethered Substrates for the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027”. J. Am. Chem. Soc. 2008, 130, 6616-6623. 3. Lin SJ, Van Lanen SG and Shen B*, “Regiospecific Chlorination of (S)-?-Tyrosyl-S-Carrier Protein Catalyzed by SgcC3 in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027”. J. Am. Chem. Soc. 2007, 129, 12432-8. 4. Van Lanen SG, Lin SJ and Shen B*, “The Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 Involves a New Branching Point in Chori *** ate Metaboli *** ” Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 494-499.( Featured in C & E News, January 14, 2008, p36) 5. Luo Y, Lin SJ, Zhang J, Cooke HA, Bruner SD and Shen B*, “Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor abtibiotic neocarzinastatin”. J. Biol. Chem. 2008, 283, 14694-14702. 6. Van Lanen SG, Lin SJ, Dorrestein PC, Kelleher NL, Shen B*, “Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027” J. Biol. Chem. 2006, 281, 29633-29640. 7. Rose NL, Completo GC, Lin SJ, McNeil M, Palcic MM*, Lowary TL*. “Expression, Purification, and Characterization of a Galactofuranosyltransferase Involved in Mycobacterium tuberculosis Arabinogalactan Biosynthesis” J. Am. Chem. Soc. 2006, 128, 6721-6729. 8. Greco A, Ho JGS, Lin SJ, Palcic MM, Rupnik M, Ng KKS*, “Carbohydrate Recognition by Clostridium difficile Toxin A” Nature Structural & Molecular Biology 2006, 13, 460-461. 9. Ma B, Audette GF, Lin SJ, Palcic MM, Hazes B, and Taylor DE*, “Purification, kiic characterization, and mapping of the minimal catalytic domain and the key polar groups of Helicobacter pylori alpha-(1,3/1,4)-fucosyltransferases” J. Biol. Chem. 2006, 281, 6385-6395. 10. Lin SJ, Tan CH, Jiang SH, Li YM and Zhu DY*, “C9-iridoids from Scrophularia buergeriana” Helvetica Chimica Acta 2006, 89, 2789-2793. 11. Bai Y, Lin SJ, Qi GZ, Palcic MM and Lowary TL*, “Synthesis of n-octyl 2,6-dideoxy-alpha-L-lyxo-hexopyranosyl-(1-2)-3-amino-3-deoxy-?-D-galacto-pyranoside, an *** og of the H-disaharide antigen” Carbohydrate Research 2006, 341, 1702-1707. 12. Ridgway KM, Shi W, Lin SJ, Palcic MM and Lowary TL*, “Chemical and chemoenzymatic synthesis of a trisaharide fragment of Tsukamurella paurometabola lipoarabinomannan”. Canadian Journal of Chemistry 2006, 84, 642-649. 13. Wang MX*, Lin SJ, Liu J and Zheng QY. “Efficient biocatalytic synthesis of highly enantiopure ?-alkylated arylglycines and amides” Advanced Synthesis & Catalysis 2004,346, 439-445. 14. Wang MX*, Lin SJ, Liu CS, Zheng QY and Li JS, “Nitrile biotransformations for highly efficient and enantioselective syntheses of electrophilic oxiranecarboxamides” J. Org. Chem. 2003, 68, 4570-4573. 15. Wang MX* and Lin SJ “Practical and convenient enzymatic synthesis of enantio-pure alpha-amino acids and amides” J. Org. Chem. 2002, 67, 6542-6545. 16. Wang MX* and Lin SJ, “Highly efficient and enantioselective synthesis of L-arylglycines and D-arylglycine amides from biotransformation of nitriles”. Tetrahedron Letters 2001, 42, 6925-6927. 17. Guo L, Lin SJ, Yang YF, Qi L, Wang MX and Chen Y*, “Fast enantioseperation of aryglycine amides by capillary eletrophoresis with highly sulfated-?-cyclodextrin as a chiral selector”. Journal of Chromatography A 2003, 998 (1-2): 221-228. 18. Guo L, Lin SJ, Dai DS, Yang YF, Qi L, Wang MX and Chen Y*, “Enantio-separation of ?-quaternary arylglycine amides by capillary electropherosis with human serum albumin” Analytical Letters 2003, 36 (7): 1451-1462. 19. Lin SJ, Jiang SH, Li YM, Zeng JF and Zhu DY*, “Two novel iridoids from Scrophularia buergeriana” Tetradron Letters 2000, 41, 1069-1071. 20. Dingle T, Wee S, Mulvey GL, Greco A, Kitova EN, Sun J, Lin SJ, Klassen JS, Palcic MM, Ng KK, Armstrong GD*, “Functional properties of the carboxy-terminal host cell-binding domains of the o toxins, TcdA and TcdB, expressed by Clostridium difficile”. Glycobiology 2008, 18, 698-706. 21. Jiang SH, Wang HQ, Li YM, Lin SJ, Tan JJ, Zhu DY*. “Two new C18-norditerpenoid alkaloids from Aconitum delavayi” Chinese Chemical letters, 2007, 18, 409-411
。
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